Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and Beyond

Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and Beyond

Blog Article

Caveolins, encoded by the CAV gene family, are the main protein components of caveolae.In most tissues, caveolin-1 (Cav-1) and caveolin-2 (Cav-2) are co-expressed, and Cav-2 targeting to caveolae depends on the formation of heterooligomers with AWAPUHI MOISTURIZING SHAMPOO Cav-1.Notwithstanding, Cav-2 has unpredictable activities, opposing Cav-1 in the regulation of some cellular processes.While the major roles of Cav-1 as a modulator of cell signaling in inflammatory processes and in immune responses have been extensively discussed elsewhere, the aim of this review is Delta 8 Hash to focus on data revealing the distinct activity of Cav-1 and Cav-2, which suggest that these proteins act antagonistically to fine-tune a variety of cellular processes relevant to inflammation.